To further characterize our latency model (11), we analyzed the state of HSV-1 chromatin in infected hiPSC-neurons after infection with a genetically engineered HSV-1 isolate, based on the KOS strain, which expressed enhanced green fluorescent protein (EGFP) and monomeric red fluorescent protein (RFP) under the control of the viral promoters ICP0 and glycoprotein C (gC), respectively. The gene discussed is GC; the disease is infection.