Furthermore, in in vitro bladder cancer cell system, we observed that the pharmacological inhibition of the USP7 deubiquitinase enhanced CCDC6 degradation, and by altering the DNA repair mechanisms mediated by homologous recombination, sensitized the bladder tumor cells to the cytotoxic effect of PARP-inhibitors. This evidence concerns the gene USP7 and urinary bladder neoplasm.