In our investigation we also reported that the RRx-001 agent, by downregulating the DNA-methyltransferase 1 (DNMT1) protein, generated in bladder cancer cells an immunomodulatory activity by inducing an interferon response through epigenetic induction of viral mimicry [7, 9, 26, 39]. This evidence concerns the gene DNMT1 and urinary bladder cancer.