CCDC6 encodes for a pro-apoptotic protein, often inactivated in thyroid and lung cancer upon fusion with various oncogenes [13–15]; CCDC6 is also impaired by somatic mutations, detected at low frequency in several tumors including bladder cancer (http://www.cbioportal.org/), as well as by its increased downregulation due to altered tuning of its modifying enzymes, the Fbxw7 E3 ubiquitin ligase and the USP7 deubiquitinase [12]. The gene discussed is USP7; the disease is urinary bladder cancer.