Furthermore, the agent RRx-001, by downregulating the DNA-methyltransferase 1 (DNMT1) protein, generated in bladder cancer cells an immunomodulatory activity, by triggering an antiviral response in absence of a real viral infection - known as “viral mimicry” - through an interferon-mediated response (Additional file 1: Figure S1A-D) [7, 9, 26]. This evidence concerns the gene DNMT1 and viral infectious disease.