In our investigation we also reported that the RRx-001 agent, by downregulating the DNA-methyltransferase 1 (DNMT1) protein, generated in bladder cancer cells an immunomodulatory activity by inducing an interferon response through epigenetic induction of viral mimicry [7, 9, 26, 39]. The gene discussed is DNMT1; the disease is urinary bladder carcinoma.