In conclusion, we believe that in high grade UBC the distribution in two clusters of CCDC6 and USP7 protein levels can possibly indicate the use of PARP-inhibitor drugs, in presence or absence of the USP7 inhibitors, and the addition of the agent RRx-001 combined with the anti immune checkpoint drugs might offer novel personalized therapeutic scheme to bladder cancer patients (Fig. 6b). Here, CCDC6 is linked to urinary bladder cancer.