The pharmacological inhibition of the deubiquitinase enzyme USP7 has shown antitumor properties in several tumor types [23] and also determined cytotoxic effects in a series of urothelial bladder cancer cells expressing appreciable levels of CCDC6 and USP7 proteins at western blot (Fig. 1a, b). The gene discussed is CCDC6; the disease is bladder transitional cell carcinoma.