Recently, in the muscle invasive form of UBC, mutations in genes involved in DNA damage response and repair, such as TP53, ATM, ERCC2, and, recently, CCDC6, have been reported at variable percentage [30, 31] [http://www.cbioportal.org], suggesting chemosensitivity or the use of PARP-inhibitor drugs for this tumor. This evidence concerns the gene TP53 and neoplasm.