PDZD7 and hepatocellular carcinoma: In addition, Lnc-PDZD7 knockdown in HepG2 cells downregulated EZH2 while Lnc-PDZD7 overexpression upregulated EZH2 in Bel-7402 cells (Fig. 4b), suggesting that Lnc-PDZD7 can promote EZH2 expression in HCC.