Song et al. [2] discovered that ATOH8 can repress stem-cell associated genes, including OCT4, NANOG, and CD133, by contacting DNA sequences harboring an E-box motif, decreasing the stemness features and chemoresistance of HCC and suggesting that ATOH8 functions as an inhibitor of stemness features in HCC. The gene discussed is PROM1; the disease is hepatocellular carcinoma.