By examining the effect of Cpn infection on validated pathways of astrocytic APP processing, this study provides evidence to support that AD pathology is recapitulated by infection with Cpn. This investigation explores how the expression and activity of APP-processing machinery, as defined by the amyloid cascade hypothesis, is altered as a result of Cpn infection of STTG1 human astrocytoma cells. Here, APP is linked to Alzheimer disease.