For example, among the 8 downregulated genes, RIPK4 (receptor-interacting serine/threonine kinase 4) promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling [34]; presumably, RIPK4 downregulation in oocytes may also inactivate Erk signaling and impair oocyte quality. Here, RAF1 is linked to familial pancreatic carcinoma.