Examples of target genes include Cadherin 13 (CDH13 interacting with rs8055236) which has previously been shown to protect against atherosclerosis in experimental models, AMP-activated protein kinase (PRKAA2 [Protein Kinase AMP-Activated Catalytic Subunit Alpha 2] interacting with rs12239436) whose activity inhibits cell migration via phosphorylation of Pdlim5 (PDZ and LIM Domain 5) and BACH1 (BTB Domain And CNC Homolog 1; interacting with rs2832227), a transcriptional regulator which has been shown to be involved in atherosclerosis development in apoE deficient mice. Here, APOE is linked to atherosclerosis.