OXTR and Anxiety: Activation of the oxytocin receptor in the median raphe nucleus has been shown to facilitate serotonin release, and oxytocin‐induced anxiolytic action is impaired by a serotonin 2A/2C antagonist, suggesting that oxytocin reduces anxiety‐related behaviour via facilitation of serotonin release,114 although it has been shown that oxytocin receptor deficiency in serotoninergic neurones has no significant effect on anxiety‐related behaviour but reduces aggressive behaviour in male mice.115