CAV3 and cardiac hypertrophy: In support of this idea, Cav‐3 KO results in a progressive cardiomyopathy characterized by ventricular hypertrophy and dilatation and reduced fractional shortening (Woodman et al., 2002), while a loss‐of‐function mutation in Cav‐3, T63S, has been associated with inherited hypertrophic cardiomyopathy (Hayashi et al., 2004).