In summary, Cav‐3 OE appears to have little effect on cardiac and cell morphology, and in vivo cardiac function, and the response to TAC was qualitatively similar in WT and Cav‐3 OE mice; however, both heart weight and cell volume were significantly smaller in Cav‐3 OE mice than in WT, following TAC. Here, CAV3 is linked to persistent truncus arteriosus.