Levin-Iaina et al. 10reported the renal IGF-1 protein is significantly upregulated in rats withStreptozotocin (STZ)-induced early DM, which is also related to renal compensatoryhypertrophy and high filtration; Li et al. 11found the serum IGF-1 level is significantly increased in patients with type2 diabetic nephropathy, which also increases the progress of DN, thus suggestingthat IGF-1 may be closely related to the occurrence and development of DN.12 The gene discussed is IGF1; the disease is liver dysplastic nodule.