The cytokines bind to receptors on the cell membrane, and the activatedreceptors produce JAK binding sites, which are activated with phosphorylation.Further studies showed that PAR-1 activation-mediated tumor cell apoptosis isassociated with tyrosine phosphorylation of JAK2 and STAT1, and translocation ofSTAT1 to the nucleus.12 This evidence concerns the gene JAK2 and neoplasm.