Consistently, comparedwith the LBP-3 group, HE staining showed that more inflammation cellsaggregation and cellular swelling and infiltration were observed in the kidneytissue after brusatol treatment (Fig. 6H).The result indicates that Nrf2 inhibition by brusatol can reverse the protectiveeffect of LBP on the LPS induced septic kidney injury. Here, NFE2L2 is linked to kidney injury.