Malignant transformation occurs in less than 1% of tumors and malignant peripheral nerve sheath tumors (MPNST) are uncommon on the pancreas and the lesser sac.TP53 mutations have been found in a subgroup of MPNSTs, indicating that a p53-mediated pathway is involved in their development [5,6]. Here, TP53 is linked to malignant peripheral nerve sheath tumor.