Among included studies for PLCE1 rs2274223 variant and digestive tract cancer, fifteen studies were about esophageal cancer (7,907 cases and 12,141 controls), ten studies were about gastric cancer (9,783 cases and 9,904 controls) and four studies were about colorectal cancer (1,040 cases and 1,314 controls). The gene discussed is PLCE1; the disease is colorectal cancer.