Stroke has been shown to be one of the leading causes of mortality and the most common cause of disability in adults in most countries.1 Although clinically effective drug (recombinant tissue plasminogen activator, rt‐PA) therapy has been achieved for acute ischaemic stroke, the majority of patients miss the optimal opportunity for vascular recanalization, owing to the narrow therapeutic window and safety concerns.2 Thus, there remains an urgent need to decipher the potential mechanisms of stroke, understanding those mechanisms will be beneficial for the clinical therapy of patients. Here, PLAT is linked to Stroke.