Fluoride can also induce apoptosis by increasing the phagocytic activity of mature ameloblasts, and the Bcl‐2 signalling pathway is involved in this process.8 Furthermore, there is evidence that autophagy is involved in dental fluorosis.4 One study9 observed that fluoride increased expression of Beclin1, which is required for autophagosome formation, and decreased the expression of mTOR, an autophagy‐related complex, indicating that autophagy is involved in dental fluorosis. The gene discussed is MTOR; the disease is dental fluorosis.