It could lead to Gi/o‐dependent Ca2+‐mobilization when activated by chemerin.25 The elevated expression level of ChemR23 was reported to be associated with inflammation and renal damage in DN mice.12 In our study, the expression level of ChemR23 significantly increased in DN patients and was positively correlated with the TGF‐β1 expression level, indicating its relation with inflammatory mediators. Here, RARRES2 is linked to liver dysplastic nodule.