In the DN mice model, inhibiting VEGF‐A could reduce endothelial activation and glomerular inflammation, therefore ultimately reversing kidney damage.30 HG was showed to induce renal glomerular endothelial hyperpermeability by damaging the tight junction between cells.31 In our study, we cultured GEnCs and then stimulated them with HG or chemerin. The gene discussed is RARRES2; the disease is Nephropathy.