However, only ChemR23 is essential for chemerin.10 ChemR23, or Chemokine like receptor 1, is a G protein‐coupled receptor that could direct leucocytes towards sites of inflammation.11 It was reported to mediate inflammation in DN rats when activated by chemerin.12 However, the role and molecular mechanism of chemerin/ChemR23 axis in renal damage during the development of DN is still unclear. This evidence concerns the gene CMKLR1 and liver dysplastic nodule.