Many lines of evidence, ranging from in vitro experiments to epidemiological studies, have demonstrated that inflammation also plays a crucial role in the pathogenesis and progression of DN.18 Currently, some management targeting cytokines such as MCP‐1 have shown a promising effect in reducing urinary protein in DN.19 In this study, we found that chemerin could induce inflammation and cause endothelial injury in DN through its receptor ChemR23. This evidence concerns the gene CCL2 and liver dysplastic nodule.