CXCL8 and liver dysplastic nodule: However, it was revealed that inflammation was also involved in some non‐infectious chronic diseases, such as type 2 diabetes mellitus and cardiovascular disease.1 Persistent inflammation in the circulation system and renal tissue was an important pathophysiological basis in the development of DN.2 Inflammatory factors, such as interleukin (IL) −6, tumour necrosis factor (TNF) ‐α, transforming growth factor (TGF) ‐β1 and IL‐8 are involved in the development of DN.