In DN, elevated expression of TGF‐β1 was often accompanied by gradual fibrosis and finally led to renal failure.29 Our study showed that in renal biopsy samples of DN patients and renal cortex of DN mice, expression levels of TGF‐β1 and other inflammatory factors increased as ChemR23 was elevated. Here, TGFB1 is linked to Renal insufficiency.