NEO1 and colorectal cancer: Netrin4 suppresses VEGF‐stimulated endothelial cell migration and tube formation by binding to the transmembrane receptor Neogenin (Neo1).7 Elevated NTN4 also decreases pancreatic and colorectal cancer growth by inhibiting tumour angiogenesis.8, 9 In the corneal mouse model, Ntn4 inhibits suture‐mediated neovascularization.10 Whether NTN4 acts as a pro‐ or anti‐angiogenic factor may be context dependent.