HMGB1/TLR4 signalling via regulating the above process, could affect the distribution of DCs in the myocardium and induce the activation and maturation of DCs, stimulate the expression of costimulatory molecules, promote the release of inflammatory factors through the MyD88/NF‐κB pathway to participate in MI/RI and aggravate myocardial injury. The gene discussed is TLR4; the disease is myocardial infarction.