HMGB1 and myocardial infarction: According to the experimental results, it is preliminarily concluded that HMGB1/TLR4 signalling pathway can regulate DCs maturation and activation, expression of costimulatory molecule and secretion of inflammatory mediators, to exert the regulation role of DCs on the differentiation and proliferation of T lymphocyte, thereby affecting the myocardial damage of DCs in MI/RI.