In addition, this study does not explain whether the HMGB1/TLR4 signalling pathway can play a role in other cells besides the injury mediated by DCs in MIR; whether DCs is affected by other pathways in addition to the HMGB1/TLR4 pathway; whether the function of the myocardial intrinsic DCs and DCs released from peripheral blood or other organs is consistent with the function in MI/RI. Here, HMGB1 is linked to myocardial infarction.