Although our results suggest a low toxicity of JPH203 towards normal cells, it is important to mention that the impairment of the transport of branched‐chain amino acids at the blood‐brain barrier caused by a LAT1 deficiency has also been described to cause autism spectrum disorders in mice.33 Hence, JPH203 could lead to psycho‐cognitive disorders in patients. This evidence concerns the gene LAT and Cognitive impairment.