EGFR and non-small cell lung carcinoma: The randomized phase IIb LUX-Lung 7 trial is, to the best of our knowledge, the first study to compare the irreversible ErbB family blocker (second-generation EGFR-targeting agent) with a reversible, first-generation EGFR TKI: in this case, afatinib was compared with gefitinib in treatment-naïve patients with advanced NSCLC harboring a common EGFR mutation (exon 19 deletion/L858R) (Park et al. 2016).