Nonetheless, PET imaging showed that caspase-3 activation can be detected using 18F-ICMT-11 in B16ovaRevC3 tumours, 6 and 24 h after death-switch induction, which was also accompanied by significantly increased expression of cleaved capase-3 in tumour sections, as demonstrated by IHC, confirming the induction of apoptosis in these tumours. This evidence concerns the gene CASP3 and neoplasm.