MRE11 and endometrial endometrioid adenocarcinoma: Here, we showed that a pathogenic MRE11(G285C) mutation detected in uterine endometrioid carcinoma (TCGA database) exhibited a similar cellular phenotype with the UFMylation-defective mutant MRE11(K282R) (Figures 7 and 8), suggesting that the role of the MRE11 UFMylation is closely associated with tumorigenesis.