Recently, it was shown that HIF prolyl hydroxylases (HIF PHDs) are required for pro-death ATF4 transcription, and a selective small molecule inhibitor of the HIF PHDs, Adaptaquin, abrogates glutamate analog (HCA)-induced ferroptosis and improves functional recovery after intracerebral hemorrhage, where cell death has also been defined as ferroptotic (Karuppagounder et al., 2016). This evidence concerns the gene ATF4 and intracerebral hemorrhage.