VCP and Paget disease: Mutations in VCP contribute to FTD, amyotrophic lateral sclerosis, inclusion body myositis and Paget’s disease (for review, see Nalbandian et al., 2011); mutations in PINK1 elicit motor and cognitive dysfunction characteristic of early-onset PD/PDD (Li et al., 2005; Ephraty et al., 2007; Ricciardi et al., 2014).