PINK1 and Parkinson disease: Loss of function mutations in PTEN-induced kinase 1 (PINK1) are linked to recessive PD (Hatano et al., 2004; Valente et al., 2004a; Samaranch et al., 2010) and early-onset PD with dementia (PDD; 2007; Li et al., 2005; Ephraty et al., 2007; Ricciardi et al., 2014).