INS and diabetes mellitus: A number of reports show that compared to high-income countries, the majority of adult patients diagnosed with DM in sub-Saharan Africa (SSA) are of median age of < 50 years (signifying early disease onset), lean body size (have low or normal BMI) and pancreatic beta cell secretory dysfunction characterised by a significantly blunted acute first phase of insulin secretion in response to an intravenous or oral glucose load predominates rather than peripheral insulin resistance [4–12].