Amoah A et al. in their study that compared 15 healthy controls without family history of DM (group 1) with 11 healthy controls with first degree family history of DM (group 2) and 10 patients with T2DM (group 3) found that group 3 had severely blunted acute phases of insulin secretion following an intravenous glucose load as measured by the absolute and incremental area under the curve [10]. The gene discussed is INS; the disease is diabetes mellitus.