When energy resources are abundant, angiogenin enters the nucleus via a M30-R-R-R-G34 nuclear translocation signal (NTS) [113, 114] and binds to a CT-repeat angiogenin binding element (ABE), promoting ribosome synthesis, ribosomal RNA transcription and maturation (specifically processing of 18S and 28S rRNA) [112, 115] and thereby driving cell proliferation in several contexts, including contributing to tumor angiogenesis [112]. This evidence concerns the gene ANG and neoplasm.