DAPk (also known as DAPk1) is the prototypic member of a family of five Ca2+/Calmodulin (CaM)-dependent serine/threonine kinases (DAPk1, DAPk2, ZIPk, DRAK-1 and DRAK-2) that are known to suppress tumor growth and metastasis, by mediating a wide range of cellular processes, including p53-dependent or independent apoptosis and autophagy [164–166]. This evidence concerns the gene DAPK1 and neoplasm.