A strategy of glioma gene- and epigenetic regulation directed by the Darwinian clonal selection during carcinogenesis is tightly linked with the acquisition of immunosuppressive functions of cancer cells, including boosted FAS-L, PD-L1 and PD-L2 expression, their proper posttranslational modifications and protein trafficking to the cell surface. The gene discussed is PDCD1LG2; the disease is glioma.