Interestingly, we observed dramatic upregulation of FAS-L expression in U87MG glioblastoma cells during the apoptotic commitment of these cells induced by CBD (see Supplementary Figure 2A and 2B), even the role of FAS-L/FAS-mediated suicide of GBM cells was not critical, due to a low endogenous expression of FAS Receptor [36]. The gene discussed is FAS; the disease is glioblastoma.