TP53 and glioma: To further extend our observation on CBD-mediated death for proneural glioma cultures at a low passage, we took advantage of two mouse glioma lines created in the laboratory of Dr. P. Canoll (Columbia University, New York): PPG2 (Pdgf+, p53−/−, Pten+/+) and MGPP3 (Pdgf+, p53−/−, Pten−/−). MGPP3 represents a mouse proneural glioma cell line [44, 45].