TGFB1 and hepatocellular carcinoma: For example, Coulouarn and colleagues compared the TGFβ response of primary hepatocytes isolated from a TGFβ receptor knockout mouse model (unresponsive to TGFβ) and from wild type mice (responsive to TGFβ), and were able to identify early and late TGFβ signatures that predict different clinical outcomes in human hepatocellular carcinomas [13].