Therefore, in this study, we used fourteen NSCLC cell lines and characterized them in terms of their response to TGFβ-1, via measurements of: growth, morphology, migration, SMAD-2 phosphorylation, transcriptional activity, and expression of EMT markers (E-cadherin 1, vimentin, SNAIL). The gene discussed is SMAD2; the disease is non-small cell lung carcinoma.