APLN and nonpapillary renal cell carcinoma: Both low APLNR and low APLN mRNA expression levels were predictive of lower overall survival in patients with ccRCC in Kaplan–Meier (Fig. 2c, d) and in univariate Cox analysis with dichotomisation based on the optimised cut-off values (APLNR: HR 2.1, 95% CI 1.6–2.9, p = 3.1e−06; APLN: HR 1.6, 95% CI 1.2–2.2, p = 0.004).