Papillary RCC (pRCC) and chromophobe RCC (chRCC) tissue samples demonstrated relatively low vascular and relatively high cytoplasmic APLNR expression in tumour cells, while clear-cell RCC (ccRCC) showed a wide spectrum of staining intensities in both cytoplasm of tumour cells and endothelium (Suppl. The gene discussed is APLNR; the disease is chromophobe renal cell carcinoma.