In the current study, we extended these findings to show lower accumulation of platinum and sensitivity to oxaliplatin-induced growth inhibition in HEK293 cells stably transfected to overexpress MRP2, and in human gastrointestinal tumour lines (HepG2 and PANC-1) with endogenous overexpression of MRP2. This evidence concerns the gene ABCC2 and digestive system neoplasm.