These amyloid fibrils are formed by intrinsically disordered proteins (IDP)2, which possess little or no 3D structure in their native state and one such example is alpha-synuclein (α-syn) which forms amyloid fibrils that contribute to the cytoplasmic inclusions, that represent the pathological hallmarks of α-synucleinopathies, such as PD, dementia with Lewy bodies, and multiple system atrophy3. The gene discussed is SNCA; the disease is Parkinson disease.