The top ten upregulated KEGG pathways were TNF signaling pathway, influenza A, NF-kappa B signaling pathway, Herpes simplex infection, cytokine-cytokine receptor interaction, measles, apoptosis, NOD-like receptor signaling pathway, Toll-like receptor signaling pathway and cytosolic DNA-sensing pathway. The gene discussed is TNF; the disease is herpes simplex infectious disease.