Although there are no studies exploring the role of STAT1/STAT2 during the polarized Th2-immune responses elicited during an active F. hepatica infection, in schistosomiasis it is well known that STAT1 is involved in the Th1 response that is prompted during the earliest phase of infection, a response that is initiated by soluble egg antigens (SEA) derived by laying eggs in the lung and liver, which makes our finding interesting since it does not follow other helminth patterns of action. Here, STAT1 is linked to infection.