Interestingly, both WB and IF assays verified that homozygous or heterozygous FBXW7 knockout in CRC cells augmented ZEB2 protein levels (e.g. Fig. 3a, left, S4B and S4C), and in murine fbxw7∆G crypts versus fbxw7fl/fl controls (Fig. 3a, right). The gene discussed is FBXW7; the disease is colorectal carcinoma.