ZEB2 and colorectal carcinoma: A higher number and larger size of metastatic foci were detected in the lungs and livers (the most common site of metastasis in CRC patients), in mice injected with HCT116FBXW7(−/−) cells, while the metastatic ability of ZEB2-shRNAK/D:HCT116FBXW7(−/−) cells was relatively low (Fig. 3e–h).