WBs and cytotoxicity analyses of ZEB2-shRNAK/D:HCT116FBXW7(−/−) cells further confirmed that induction of ZEB2/EMT through the loss of SCFFBXW7-E3-ligase activity induced resistance to 5-fluorouracil (5-FU) and Oxaliplatin (OX) chemotherapeutics in CRC cells (Fig. 4f, g and S6G). This evidence concerns the gene ZEB2 and colorectal carcinoma.