It is also exciting to explore the significance of GSK3β, its active (i.e. phospho-GSK3βTyr216) versus inactive form (i.e. phospho-GSK3βSer9) in the regulation of FBXW7-induced ZEB2 degradation and their correlation with clinical markers in the tumours (e.g. primary, advanced) and their normal counterparts. The gene discussed is GSK3B; the disease is neoplasm.