Consistent with a recent report27, an increased Vimentin, N-cadherin, ZEB1, Snail1 and reduced E-cadherin expression levels were found both in FBXW7(−/−) CRC cell lines and fbxw7∆G crypts, suggesting that FBXW7 depletion induces EMT (e.g. Fig. 3a, c right, S5C, S5D and S6 A-D). Here, ZEB1 is linked to colorectal carcinoma.