Although immunohistochemical analyses show that kindlin-2 level is increased in human lung adenocarcinoma (Fig. 8a, c) and KO studies in mice demonstrate that increase of kindlin-2 level promotes lung adenocarcinoma progression and increases mortality rate (Fig. 9), how kindlin-2 level is increased remains to be determined. This evidence concerns the gene FERMT2 and lung adenocarcinoma.