In this regard, it is worth noting that the level of PYCR1 is also significantly increased in human lung adenocarcinoma (Fig. 8b, d); analyses of PYCR1 mRNA level in human patients with lung adenocarcinoma also failed to reveal a significant correlation between increase of PYCR1 mRNA level and that of mortality rate, albeit patients with higher mRNA levels of PYCR1 tended to have worse overall survival rates (Supplementary Fig. 5). This evidence concerns the gene PYCR1 and lung adenocarcinoma.