The clinical relevance of the data presented here is based on revealing the molecular and cellular mechanisms of the beneficial effects of propolis on oral health.1–3 Its major bioactive component (CAPE) protects against ligature-induced periodontitis4 and systemic bone loss by cortisone5 and supports bone defect healing.6 Considering that periodontal disease is caused by chronic inflammation9 and oxidative stress10,11 and that CAPE suppresses inflammation and oxidative damage, our in vitro findings provide indirect support for HO1 as a target of periodontal therapy. The gene discussed is HMOX1; the disease is periodontal disorder.