KIF21A and posterior cortical atrophy: PCa cells treated with DHA presented decreased levels of H3K27me3 at specific gene loci (ANKRD30BL, Dnmt3A, KIF21A and MYC promoter) compared with cells treated with DMSO (Fig. 6d and Fig. S11), suggesting that DHA affects H3K27me3 methyltransferase activity.