Amongst the remaining 46 articles for full-text evaluation, 24 articles were biochemical studies, reviews, or meta-analysis; 6 articles studied non-cancer diseases such as autoimmune diseases; 2 articles analyzed several FOXP3 polymorphisms that were not studied in other independent researches, resulting in the impossibility of data pooling; 2 articles failed to offer sufficient data for calculation. This evidence concerns the gene FOXP3 and autoimmune disease.