Since both EBV and KSHV infections are associated with multiple malignancies, along with the observation that both EBV and KSHV use EphA family receptors, it will be of interest to determine if EphA2 and EphA4 play a role in the development of KSHV- and/or EBV-associated cancers not only as entry receptors. The gene discussed is EPHA2; the disease is cancer.