Several viral proteins, such as ORFK1 (K1) (9), ORFK2 (vIL6) (9), ORF45 (10), and ORF74 (vGPCR) (11, –, 13), induce the mTOR pathway in PEL as well as in Kaposi’s sarcoma (KS). This evidence concerns the gene MTOR and Kaposi's sarcoma.