In spleens, the infected MΦ population changed over the course of infection, with red pulp MΦs (CD68+ CD11blow F4-80high MHC IIlow CD115+ CD172a+), marginal zone MΦs (CD68+ CD11b+ F4-80− SIGNR1+), tingible body MΦs (CD68+ CD11b−), and metallophilic MΦs being infected in the early acute and acute phase of infection, whereas metallophilic MΦs constituted the majority of infected spleen MΦs in the late phase of infection. This evidence concerns the gene ITGAM and infection.