A recent study from Jin et al. [34] examined the interaction and feedback loop between NF-κB and FOXM1/β-catenin in leukemia stem cells (LSCs) in chronic myelogenous leukemia and disruption of the positive feedback loop could impair LSC self-renewal capacity and eliminate LSCs. The gene discussed is NFKB1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.