Certain primary immunodeficiency conditions, such as epidermodysplasia verruciformis, hyper-IgE syndrome, idiopathic CD4 lymphopaenia, GATA2 deficiency and Warts-hypogammaglobulinaemia, infections and myelokathesis (WHIM) or Netherton’s syndrome, have the presence of cutaneous warts as one of the main clinical manifestations of the disease [83]. This evidence concerns the gene GATA2 and epidermodysplasia verruciformis.