Interestingly, when Rosiglitazone, a known PPARγ agonist, was administered in concert with nicotine to pregnant dams, asthma-like changes and H3 acetylation induced by nicotine exposure was prevented whilst nicotine induced global H4 acetylation and DNA methylation persisted [145], further reinforcing the significance of PPARγ’s role in healthy lung development. Here, PPARG is linked to asthma.