IL13 and Increased total eosinophil count: Similarly, allergen challenge elicited an ameliorated atopic response demonstrated by eosinophilia and significantly higher IL-13 levels in two subsequent generations when compared to the progeny of ambient air exposed animals [88]; METS exposure and allergen challenge were shown to deregulate miR-130, miR-16 and miR-221 exposure and are postulated as the epigenetic mechanism modulating the augmented IL-13 response induced by METS exposure [88].