In the subgroup for HIF-1α expression and DFS, HIF-1α overexpression showed poor DFS in the non-Asian (HR = 1.87, 95% CI 1.15–3.04, P = 0.011), the Asian regions (HR = 2.21, 95% CI 1.30–3.78, P = 0.004), osteosarcoma (HR = 2.21, 95% CI 1.30–3.78, P = 0.004), and chondrosarcoma (HR = 1.87, 95% CI 1.15–3.04, P = 0.011). This evidence concerns the gene HIF1A and osteosarcoma.