The relation between HIF-1α overexpression and the OS of patients with bone tumor was also present in studies with less than 100 months (HR = 2.55, 95% CI 1.97–3.30, P <  0.001) as well as more than or equal 100 months follow-up time (HR = 2.76, 95% CI 1.88–4.04, P <  0.001). The gene discussed is HIF1A; the disease is bone neoplasm.