For OS, in the subgroup analysis based on histological type, the results showed that HIF-1α overexpression existed poor OS in osteosarcoma (HR = 2.60, 95% CI 2.09–3.24, P <  0.001) and chondrosarcoma (HR = 2.83, 95% CI 1.11–7.22, P = 0.030). Here, HIF1A is linked to osteosarcoma.