TCGA data from R2: Genomics Analysis and Visualization Platform (http://r2.amc.nl) revealed that MCM3AP-AS1 was more highly expressed in HCC with high tumor grades (G3 + G4) than that in HCC with low tumor grades (G1 + G2) (P = 0.0032, Fig. 2a). The gene discussed is MCM3AP; the disease is hepatocellular carcinoma.