Among these genes, only thyroid hormone receptor interactor 12 (TRIP12) [33], cullin 4B (CUL4B) [34], FOXA1 [27, 35, 36], BTB domain containing 7 (BTBD7) [37] and heparin binding EGF like growth factor (HBEGF) [38] were reported to be oncogenes in HCC. The gene discussed is HBEGF; the disease is hepatocellular carcinoma.