In combination with trametinib (MEK inhibitor), buparlisib 60 mg daily plus trametinib 1.5 mg daily displayed promising antitumor activity in patients with KRAS-mutant ovarian cancer, however, modest antitumor activity was observed in patients with non–small cell lung cancer and pancreatic cancer [113]. Here, MAP2K7 is linked to pancreatic neoplasm.