HSPD1 and amyotrophic lateral sclerosis: Indeed, in ALS, other endogenous ligands for these innate immune receptors, such as heat shock protein 60 (HSP60), HSP70 and S100β protein, have been implicated in disease progression of ALS and their inhibition reduces inflammation and ALS disease parameters, suggesting they could contribute to the disease pathogenesis through TLR or RAGE activation.