Treatment with inhibitor(s) targeting this pathway including KRT16-siRNA, c-Met inhibitor (foretinib), protein tyrosine kinase inhibitor (genistein), and β5-integrin antibody (ITGB5-ab) in combination with a commonly used chemotherapeutic agent, 5-fluorouracil (5-FU), in OSCC resulted in significantly enhanced cytotoxicity and tumor killing effects in OSCC cells. Here, KRT16 is linked to neoplasm.