In the analysis of overall population, IL-6-174 G/C polymorphism did not appear to be associated with the mortality of sepsis in dominant model (P = 0.812, OR = 1.050, 95% CI: 0.705–1.563), recessive model (P = 0.444, OR = 1.299, 95% CI: 0.665–1 = 2.538), codominant model (GC vs. GG: P = 0.825, OR = 1.045, 95% CI: 0.709–1.540; CC vs. GG: P = 0.465, OR = 1.340, 95% CI: 0.611–2.939) and allelic model (P = 0.558, OR = 1.103, 95% CI: 0.795–1.531). The gene discussed is IL6; the disease is Sepsis.