The analysis resulted in no association between IL-6-174 G/C polymorphism and the risk of sepsis concerning the overall population under dominant model, recessive model, codominant model and allelic model (dominant model: P = 0.743, OR = 0.965, 95% CI: 0.782–1.192; recessive model: P = 0.96, OR = 0.992, 95% CI: 0.726–1.356; codominant model GC vs. GG: P = 0.57, OR = 0.950, 95% CI: 0.686–1.435; codominant model CC vs. GG: P = 0.966, OR = 0.992, 95% CI: 0.686–1.435; allelic model: P = 0.894, OR = 1.014, 95% CI: 0.831–1.236) (Fig. 2). Here, IL6 is linked to Sepsis.